Dementia and COVID-19, a Bidirectional Liaison: Risk Factors, Biomarkers, and Optimal Health Care
نویسندگان
چکیده
Cognitive impairment following SARS-CoV-2 infection is being increasingly recognized as an acute and possibly also long-term sequela of the disease. Direct viral entry well systemic mechanisms such cytokine storm are thought to contribute neuroinflammation in these patients. Biomarkers COVID-19-induced cognitive currently lacking, but there some limited evidence that could preferentially target frontal lobes, suggested by behavioral dysexecutive symptoms, fronto-temporal hypoperfusion on MRI, EEG slowing regions, hypometabolism 18F-FDG-PET. Possible confounders include due hypoxia mechanical ventilation post-traumatic stress disorder. Conversely, patients already suffering from dementia, their caregivers, have been greatly impacted disruption care caused COVID-19. Patients with dementia experienced worsening cognitive, behavioral, psychological rate COVID-19-related deaths disproportionately high among cognitively impaired people. Multiple factors, difficulties remembering executing safeguarding procedures, age, comorbidities, residing homes, poorer access hospital standard play a role increased morbidity mortality. Non-pharmacological interventions new technologies shown potential for management support caregivers.
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ژورنال
عنوان ژورنال: Journal of Alzheimer's Disease
سال: 2021
ISSN: ['1387-2877', '1875-8908']
DOI: https://doi.org/10.3233/jad-210335